In 1991, Operation Smile went to China and conducted its first medical mission in Hangzhou City.

In 2014, Operation Smile started a partnership together with Johnson & Johnson in China and launched the “Making Smiles, Changing Lives” initiative.

In March 2015, Operation Smile, Johnson & Johnson and the China Charity Foundation partnered to facilitate a medical program at Beijing Tongren Hospital that was attended by Alex Gorsky, Johnson & Johnson CEO and Bill Magee, Operation Smile Co-Founder and CEO.

In July 2015, Operation Smile and China Charities Aid Foundation For Children (CCAFC) partnered to establish the Operation Smile Special Fund of CCAFC.

As of 2016, the number of the patients in China treated by Operation Smile stands at 30,000.